Rebounding of COVID-19 symptoms, not long COVID-19 or reinfection, can occur after a period of feeling well.

Rebound COVID-19 is characterized by a temporary recurrence of symptoms that start a few days post-recovery.

Up to 10% of patients may experience this rebound, which could be more prevalent with Paxlovid treatment.

Who gets rebound COVID-19?

Research indicates that in some cases, Paxlovid treatment may lead to a resurgence of COVID-19 symptoms.

It’s important to note that the medication itself is not the cause of the rebound symptoms.

Paxlovid has shown great effectiveness in treating COVID-19 patients who are at risk of severe illness.

Doctors recommend closely monitoring patients who have received Paxlovid treatment to quickly address any potential rebound symptoms and provide appropriate care.

It is crucial for healthcare providers to educate patients about the possibility of rebound COVID-19 and the importance of reporting any new or worsening symptoms after treatment.

Soniya S. Gandhi, MD, MPH

Soniya S. Gandhi, MD, MPH is a highly accomplished physician and public health professional with expertise in both clinical medicine and public health policy. She holds a Doctor of Medicine (MD) degree and a Master of Public Health (MPH) degree, demonstrating her commitment to improving healthcare outcomes for individuals and populations.
Dr. Gandhi has a strong background in epidemiology, health promotion, and disease prevention. She has published research on a wide range of topics, including the impact of social determinants of health on health disparities, the effectiveness of public health interventions, and the role of healthcare providers in promoting healthy behaviors.
In addition to her research and clinical work, Dr. Gandhi is passionate about medical education and mentorship. She has taught medical students, residents, and fellows, and has been recognized for her dedication to training the next generation of healthcare professionals.
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Why is rebound COVID more common after treatment?

Rebound COVID-19 might be triggered by a resurgence of the virus post-Paxlovid treatment.

Addressing this issue may require a longer treatment duration or a second round of medication.

Further research is necessary to determine the exact reasons behind rebound COVID-19.

Some potential factors contributing to rebound COVID-19 after treatment may include:

• Development of viral resistance to the initial treatment
• Inadequate duration or dosage of treatment
• Patient factors such as immune status or underlying health conditions

Healthcare providers should closely monitor patients post-treatment to detect any signs of viral rebound and adjust treatment plans accordingly.

How do I know if I am experiencing a rebound?

Detecting a rebound involves closely monitoring symptom progression after recovering from COVID-19.

If symptoms reappear after a period of feeling better, it is likely a rebound case.

Seek guidance from a healthcare professional to identify and address a rebound situation.

It is important to differentiate between a rebound and a new infection. Rebound cases typically occur within weeks of recovery from COVID-19 and involve the return of previously experienced symptoms. If you notice a recurrence of symptoms such as fever, cough, shortness of breath, or fatigue, it may be indicative of a rebound.

Monitoring your symptoms and seeking medical advice promptly can help in managing a rebound effectively. Keep track of any changes in your health and communicate them to your healthcare provider for proper evaluation and guidance.

What else should I know?

Rebounds can also be experienced after recovering from respiratory illnesses like colds.

While common, rebound cold symptoms typically do not pose a serious risk.

Recovery from rebound COVID-19 generally involves mild symptoms that subside within a few days.

Understanding the persistence of cold symptoms beyond the usual recovery phase is crucial.

It is important to stay hydrated and get plenty of rest to help your body fight off lingering cold symptoms.

If your symptoms persist for more than two weeks or worsen, it is important to see a healthcare provider for further evaluation.

Other signs that your body is fighting a cold include:

• Sore throat: This is a common symptom of a cold and is caused by inflammation in the throat as your body tries to fight off the virus.
• Fatigue: When your body is working hard to fight an infection, it can leave you feeling tired and rundown.
• Fever: A low-grade fever is a sign that your body is trying to kill off the virus causing your cold.
• Body aches: Muscle aches and pains can be a result of your body’s response to the infection.
• Sneezing and congestion: These symptoms are your body’s way of trying to expel the virus from your system.

It’s important to rest, stay hydrated, and allow your body time to recuperate when fighting a cold. If symptoms persist or worsen, it’s always a good idea to consult with a healthcare provider.

How Long Do Cold Symptoms Last?

Cold symptoms typically resolve within a week to 10 days, with recovery dependent on proper rest and hydration.

Why Do Some Colds Get Worse After a Week?

A lingering cough post-cold could signal secondary infections or underlying health issues.

Anxiety about severe complications from persistent cold symptoms is common but usually unwarranted.

Persistent Cold Symptoms

If a chronic cough lasts over eight weeks, imaging or testing may be necessary to rule out serious conditions.

While persistent cold symptoms are unlikely to be cancer-related, monitoring for any concerning changes is advised.

Cold Symptoms Timeline

Cold symptoms progress through early, active, and late stages, each representing a different phase of the body’s response to the virus.

In the early stage, symptoms typically include a runny or stuffy nose, sneezing, sore throat, and possibly a mild cough. These symptoms usually last for 1-3 days.

The active stage is when symptoms intensify, with increased nasal congestion, a worsening cough, and fatigue setting in. This stage can last from 3-5 days.

Finally, the late stage is marked by lingering symptoms, such as a persistent cough, ongoing fatigue, and general malaise. This stage can last up to 2 weeks or longer, depending on the individual’s immune response.

Signs Your Cold is Getting Better

As your cold symptoms improve, you’ll notice a reduction in nasal discharge and fatigue, and your energy levels will return to normal.

If persistent cold symptoms are a concern, consult with a healthcare provider or visit an urgent care facility for tests and guidance.

Feeling like you frequently fall ill? You’re not alone.

While some individuals rarely get sick, others experience frequent colds. Most people get sick multiple times a year, according to experts.

Coping with recurrent cold symptoms can be frustrating, but for some, it’s a regular occurrence.

“Some individuals are always battling illnesses, while others seem to have stronger immunity,” notes one expert.

Although everyone faces illnesses, some are more susceptible to common colds, flu, and viruses.

If you find yourself frequently getting sick, factors such as your age and exposure to illnesses may play a role.

Increased exposure during cold and flu season can heighten the risk of falling ill.

Whether you seldom get sick or are frequently under the weather, there are measures to prevent colds and maintain good health.

Why do I get colds so often?

How Many Colds Per Year Do People Normally Get?

Is it normal to frequently fall ill? What is the average number of colds per year?

Your likelihood of getting sick is influenced by your interactions with others and activities that expose you to risk, explains Dr. Thomas Murray.

Research suggests that adults experience fewer colds than children. Enhanced hygiene practices have reduced colds in kids to 4-6 per year.

“As an adult, you can expect to have 2-3 colds annually,” states one expert.

So, Why Do I Keep Getting Colds?

Various factors, including virus exposure and your immune system’s response, affect how often you get sick.

Your habits related to hygiene and social interactions can impact your chances of catching a cold, as highlighted by Dr. Murray.

Your age plays a role in the frequency of colds; young children are more susceptible due to their developing immunity, according to an expert.

Differences in individual immune systems determine the likelihood of falling ill after being exposed to pathogens, explains another expert.

Underlying health conditions can influence your immune response, potentially leading to frequent illnesses, notes Dr. Murray.

Your Level of Exposure

Your risk of getting sick is influenced by virus exposure and immune responses, as described by one expert.

Hygiene practices and social behaviors contribute to the frequency of colds, notes Dr. Murray.

Your Age

Due to their limited immunity, children are more prone to colds, as explained by one expert.

Preschoolers, in particular, face a high risk due to poor hygiene and close contact with other children, as noted by an expert.

Your Immune System

Variances in immune systems determine susceptibility to illnesses post-exposure, explains one expert.

Underlying conditions may impact the immune system’s response, potentially leading to recurrent illnesses, states Dr. Murray.

Individuals with weakened immune systems are more vulnerable to infections, notes an expert.

Multiple Viruses Circulating

Exposure to multiple circulating illnesses can heighten your risk of falling ill, caution experts.

In recent seasons, a triple threat of flu, RSV, and COVID-19 cases surged simultaneously, creating a “tripledemic,” experts report.

New COVID-19 variants are emerging in 2025, with reported cases across the U.S.

How To Stop Getting Sick All the Time:

Following prevention measures diligently can reduce your susceptibility to colds, advise experts.

Emphasizing hygiene practices and taking precautions can minimize your exposure to viruses, as highlighted by one expert.

Limit Exposure to People Who Are Sick.

To prevent the spread of illnesses, distance yourself from sick individuals and stay home if you’re unwell, suggests an expert.

Wash Your Hands Frequently.

Regular hand-washing and proper etiquette are key to preventing colds, stress experts.

Using hand sanitizer when hand-washing is not possible can also be effective, adds another expert.

Wear a Mask in Shared Spaces.

Avoiding crowded indoor spaces and wearing a mask are recommended steps to prevent the spread of illnesses, according to experts.

Masks not only protect you but also prevent transferring viruses from surfaces to your face, experts point out.

Keep an Eye on What Illnesses Are Going Around.

Remaining informed about circulating viruses in your region can help safeguard your health, experts advise.

Test For COVID-19.

Even mild cold-like symptoms should be evaluated for COVID-19 to rule out severe illness, experts recommend.

Staying updated on flu and COVID-19 vaccinations is crucial for preventing severe diseases, as recommended by Dr. Murray.

Receiving both vaccines during the same visit can streamline your protection against illnesses, suggest experts.

Older adults and infants can receive RSV vaccines for protection, while pregnant individuals can get vaccinated to prevent RSV in newborns.

Maintain a Healthy Lifestyle Generally.

To boost your immune system, engage in healthy habits like exercise, a balanced diet, stress management, and adequate sleep. While vitamin C supplements may not prevent colds, sticking to these practices is recommended for overall well-being.